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Article

VP4 Mutation Boosts Replication of Recombinant Human/Simian Rotavirus in Cell Culture.

Viruses - 5 Apr 2024

Valusenko-Mehrkens Roman, Schilling-Loeffler Katja, Johne Reimar, Falkenhagen Alexander

Abstract excerpt

Rotavirus A (RVA) is the leading cause of diarrhea requiring hospitalization in children and causes over 100,000 annual deaths in Sub-Saharan Africa. In order to generate next-generation vaccines against African RVA genotypes, a reverse genetics system based on a simian rotavirus strain was utilized here to exchange the antigenic capsid proteins VP4, VP7 and VP6 with those of African human rotavirus field...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38675907
DOI: 10.3390/v16040565
PMCID: PMC11054354

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