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Article

Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern

6 Apr 2020

Abstract excerpt

BACKGROUND: Crohn's disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated that human adipose-derived stem cells (hASCs) from CF of patients with CD exhibit dysfunctional phenotypes, including a pro-inflammatory profile, high phagocytic capacity, and weak immunosuppressive...

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PMID: 32252817
DOI: 10.1186/s13148-020-00843-3

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