Article
Smoking Suppresses the Therapeutic Potential of Adipose Stem Cells in Crohn's Disease Patients through Epigenetic Changes.
Cells - 27 Mar 2023
Boronat-Toscano Albert, Vañó Irene, Monfort-Ferré Diandra, Menacho Margarita, Valldosera Gemma, Caro Aleidis, Espina Beatriz, Mañas Maria José, Marti Marc, Espin Eloy, Saera-Vila Alfonso, Serena Carolina
Abstract excerpt
Patients with Crohn's disease (CD) who smoke are known to have a worse prognosis than never-smokers and a higher risk for post-surgical recurrence, whereas patients who quit smoking after surgery have significantly lower post-operative recurrence. The hypothesis was that smoking induces epigenetic changes that impair the capacity of adipose stem cells (ASCs) to suppress the immune system. It was also questioned...
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