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Article

PRDM16 suppresses HIF-targeted gene expression in kidney cancer.

The Journal of experimental medicine - 1 Jun 2020

Kundu Anirban, Nam Hyeyoung, Shelar Sandeep, Chandrashekar Darshan S, Brinkley Garrett, Karki Suman, Mitchell Tanecia, Livi Carolina B, Buckhaults Phillip, Kirkman Richard, Tang Yawen, Rowe Glenn C, Wei Shi, Varambally Sooryanarayana, Sudarshan Sunil

Abstract excerpt

Analysis of transcriptomic data demonstrates extensive epigenetic gene silencing of the transcription factor PRDM16 in renal cancer. We show that restoration of PRDM16 in RCC cells suppresses in vivo tumor growth. RNaseq analysis reveals that PRDM16 imparts a predominantly repressive effect on the RCC transcriptome including suppression of the gene encoding semaphorin 5B (SEMA5B). SEMA5B is a HIF target gene...

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Identifiers

PMID: 32251515
DOI: 10.1084/jem.20191005
PMCID: PMC7971134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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