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Article

SETD2 loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a TGF ‐β‐independent manner

7 Jul 2023

Abstract excerpt

Histone-lysine N-methyltransferase SETD2 (SETD2), the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on histone H3 (H3K36me3), is often mutated in clear cell renal cell carcinoma (ccRCC). SETD2 mutation and/or loss of H3K36me3 is linked to metastasis and poor outcome in ccRCC patients. Epithelial-to-mesenchymal transition (EMT) is a major pathway that drives invasion and metastasis in...

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PMID: 37418588
DOI: 10.1002/1878-0261.13487

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Related research

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SETD2 loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a TGF ‐β‐independent mannerPMID 37418588Read ↗

Loss of SETD2, but not H3K36me3, correlates with aggressive clinicopathological features of clear cell renal cell carcinoma patients.Semantic proximity Read ↗

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SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signaling pathway in the absence of VHLSemantic proximity Read ↗

Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma.Semantic proximity Read ↗

Loss of histone H3 lysine 36 trimethylation is associated with an increased risk of renal cell carcinoma-specific death.Semantic proximity Read ↗

Revealing the characteristics of SETD2-mutated clear cell renal cell carcinoma through tumor heterogeneity analysisSemantic proximity Read ↗

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.Semantic proximity Read ↗

Multilevel Regulation of β-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

SETD2 methyltransferase activity aids gene definition by promoting correct transcription initiation and terminationSemantic proximity Read ↗

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Semantic proximity Read ↗

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