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Article

Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster.

The American journal of pathology - 1 Nov 2010

Mengelbier Linda Holmquist, Karlsson Jenny, Lindgren David, Øra Ingrid, Isaksson Margareth, Frigyesi Ildiko, Frigyesi Attila, Bras Johannes, Sandstedt Bengt, Gisselsson David

Abstract excerpt

Wilms tumor is the most common pediatric renal neoplasm, but few molecular prognostic markers have been identified for this tumor. Somatic deletion in the long arm of chromosome 16 (16q) is known to predict a less favorable outcome in Wilms tumor, but the underlying molecular mechanisms are not k...

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Share to Chromosomes, Human, Pair 16
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20847289
DOI: 10.2353/ajpath.2010.100130
PMCID: PMC2966816

Genes

IRX3
IRX5
IRX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20847289-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster.PMID 20847289Read ↗

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