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Article

In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate.

Cancer science - 1 Sept 2006

Umemura Takashi, Kanki Keita, Kuroiwa Yuichi, Ishii Yuji, Okano Keita, Nohmi Takehiko, Nishikawa Akiyoshi, Hirose Masao

Abstract excerpt

To clarify the role of 8-OHdG formation as a starting point for carcinogenesis, we examined the dose-dependence and time-course of changes of OGG1 mRNA expression, 8-OHdG levels and in vivo mutations in the kidneys of gpt delta rats given KBrO3 in their drinking water for 13 weeks. There were no remarkable changes in OGG1 mRNA in spite of some increments being statistically significant. Increases of 8-OHdG...

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Identifiers

PMID: 16805826
DOI: 10.1111/j.1349-7006.2006.00248.x
PMCID: PMC11158994

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate.PMID 16805826Read ↗

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