Analysis of SNP Array Abnormalities in Patients with DE NOVO Acute Myeloid Leukemia with Normal Karyotype.

doi:10.1038/s41598-020-61589-9

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Article

Analysis of SNP Array Abnormalities in Patients with DE NOVO Acute Myeloid Leukemia with Normal Karyotype.

Scientific reports - 3 Apr 2020

Ibáñez Mariam, Such Esperanza, Onecha Esther, Gómez-Seguí Inés, Liquori Alessandro, Sellés Jorge, Hervás-Marín David, Barragán Eva, Ayala Rosa, LLop Marta, López-Pavía María, Rapado Inmaculada, Neef Alex, Sanjuan-Pla Alejandra, Sargas Claudia, Gonzalez-Romero Elisa, Boluda-Navarro Mireia, Andreu Rafa, Senent Leonor, Montesinos Pau, Martínez-López Joaquín, Angel Sanz Miguel, Sanz Guillermo, Cervera José

Abstract excerpt

Nearly 50% of patients with de novo acute myeloid leukemia (AML) harbor an apparently normal karyotype (NK) by conventional cytogenetic techniques showing a very heterogeneous prognosis. This could be related to the presence of cryptic cytogenetic abnormalities (CCA) not detectable by conventional methods. The study of copy number alterations (CNA) and loss of heterozygozity (LOH) in hematological malignancies is...

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Identifiers

PMID: 32246042
DOI: 10.1038/s41598-020-61589-9
PMCID: PMC7125150

Genes

DNMT3A
FLT3
NPM1

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Source receipt: pubmed, retrieved 6 Sept 2026.

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