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Article

Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review.

British journal of haematology - 1 Jun 2007

Baldus Claudia D, Mrózek Krzysztof, Marcucci Guido, Bloomfield Clara D

Abstract excerpt

Normal cytogenetics are detected pretreatment in approximately 45% of patients with de novo acute myeloid leukaemia (AML); thus this constitutes the single largest cytogenetic group of AML. Recently, molecular genetic alterations with prognostic significance have been reported in these patients. They include internal tandem duplication of the FLT3 gene, partial tandem duplication of the MLL gene, mutations of the...

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Identifiers

PMID: 17488484
DOI: 10.1111/j.1365-2141.2007.06566.x

Genes

BAALC
ERG
FLT3
NPM1

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