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Article

New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Nov 2009

Tiu Ramon V, Gondek Lukasz P, O'Keefe Christine L, Huh Jungwon, Sekeres Mikkael A, Elson Paul, McDevitt Michael A, Wang Xiao Fei, Levis Mark J, Karp Judith E, Advani Anjali S, Maciejewski Jaroslaw P

Abstract excerpt

PURPOSE: Cytogenetics is the primary outcome predictor in acute myeloid leukemia (AML). Metaphase cytogenetics (MC) detects an abnormal karyotype in only half of patients with AML, however. Single nucleotide polymorphism arrays (SNP-A) can detect acquired somatic uniparental disomy (UPD) and other cryptic defects, even in samples deemed normal by MC. We hypothesized that SNP-A will improve detection of...

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Identifiers

PMID: 19770377
DOI: 10.1200/JCO.2009.21.9840
PMCID: PMC2773477

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EFS

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