Article
Role of the carboxy terminus of SecA in iron acquisition, protein translocation, and virulence of the bacterial pathogen Acinetobacter baumannii.
Infection and immunity - 1 Apr 2015
Fiester Steven E, Nwugo Chika C, Penwell William F, Neary John M, Beckett Amber C, Arivett Brock A, Schmidt Robert E, Geiger Sarah C, Connerly Pamela L, Menke Sharon M, Tomaras Andrew P, Actis Luis A
Abstract excerpt
Acinetobacter baumannii is a Gram-negative opportunistic nosocomial pathogen that causes pneumonia and soft tissue and systemic infections. Screening of a transposon insertion library of A. baumannii ATCC 19606T resulted in the identification of the 2010 derivative, which, although capable of growing well in iron-rich media, failed to prosper under iron chelation. Genetic, molecular, and functional assays showed...
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