Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lynch syndrome and colorectal cancer: A review of current perspectives in molecular genetics and clinical strategies

1 Jan 2025

Abstract excerpt

Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), is an inherited condition associated with a higher risk of colorectal cancer (CRC) and other cancers. It is caused by germline mutations in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6 and PMS2. These mutations lead to microsatellite instability (MSI) and defective DNA repair mechanisms, resulting in increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal and Anal Carcinomas
Share to Genetic factors in colorectal cancer

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40612862
DOI: 10.32604/or.2025.063951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lynch syndrome and colorectal cancer: A review of current perspectives in molecular genetics and clinical strategiesPMID 40612862Read ↗

Lynch syndrome in the 21st century: clinical perspectives.Semantic proximity Read ↗

Genetics, diagnosis and treatment of Lynch syndrome: Old lessons and current challenges (Review)Semantic proximity Read ↗

Recent advances in Lynch syndromeSemantic proximity Read ↗

Current clinical topics of Lynch syndrome.Semantic proximity Read ↗

New Insights into Lynch Syndrome: A Narrative Review.Semantic proximity Read ↗

Lynch Syndrome: Current Status of CRC in Biotechnological and Biomedical FieldsSemantic proximity Read ↗

Lynch-like Syndrome: Potential Mechanisms and ManagementSemantic proximity Read ↗

Lynch syndrome: from detection to treatmentSemantic proximity Read ↗

Lynch Syndrome: An Updated ReviewSemantic proximity Read ↗

How Should We Test for Lynch Syndrome? A Review of Current Guidelines and Future StrategiesSemantic proximity Read ↗

Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in OncologySemantic proximity Read ↗

Lynch Syndrome in Context of the Updated German S3 Guideline Colorectal Cancer: Implementation of Universal MMR/MSI Testing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.