Article
Colorectal cancer in Lynch syndrome associated with PMS2 and MSH6 mutations.
International journal of colorectal disease - 1 Feb 2020
Yılmaz Ali, Mirili Cem, Bilici Mehmet, Tekin Salim Başol
Abstract excerpt
BACKGROUND: It is known that colorectal cancers (CRC) are frequently seen and constitute an important part of cancer-related deaths. Lynch syndrome (LS) is responsible for 3-5% of CRCs and develops due to mutations in DNA mismatch repair (MMR) genes. The most important MMR genes are MutL homolog1 (MLH1), mutS homolog 2 (MSH2), mutS homolog 6 (MSH6) and postmeiotic segregation increased 2 (PMS2). PMS2 and MSH6...
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