Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma

31 Jan 2018

Abstract excerpt

Recently, a genome-wide association study showed that a single nucleotide polymorphism (SNP) -rs11706832-in intron 2 of the human LRIG1 (Leucine-rich repeats and immunoglobulin-like domains 1) gene is associated with susceptibility to glioma. However, the mechanism by which rs11706832 affects glioma risk remains unknown; additionally, it is unknown whether the expression levels of LRIG1 are a relevant determinant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolin-1 and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma Diagnosis and Treatment

Share to Signaling Pathways in Disease

Source

Identifiers

PMID: 29391393
DOI: 10.1038/s41389-017-0012-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lrig1 is a haploinsufficient tumor suppressor gene in malignant gliomaPMID 29391393Read ↗

Lrig2-Deficient Mice Are Protected against PDGFB-Induced GliomaSemantic proximity Read ↗

The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and DiseasesSemantic proximity Read ↗

Correlation between ITGB2 expression and clinical characterization of glioma and the prognostic significance of its methylation in low-grade glioma(LGG)Semantic proximity Read ↗

A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.Semantic proximity Read ↗

LRIG1 regulates invasion and migration of human gliomas through SNAI2 and E-cadherinSemantic proximity Read ↗

Leucine-rich glioma inactivated 3: Integrative analyses reveal its potential prognostic role in cancer.Semantic proximity Read ↗

A Transcriptional Signature of PDGF-DD Activated Natural Killer Cells Predicts More Favorable Prognosis in Low-Grade Glioma.Semantic proximity Read ↗

Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines.Semantic proximity Read ↗

Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples.Semantic proximity Read ↗

Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasivenessSemantic proximity Read ↗

LRG1 modulates invasion and migration of glioma cell lines through TGF-β signaling pathwaySemantic proximity Read ↗

Promoter Hypermethylation-mediated Inactivation of LRRC4 in GliomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.