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Article

T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma

1 Mar 2020

Abstract excerpt

Background Malignant pleural mesothelioma (MPM) is a highly lethal malignancy in need for new treatment options. Although immunotherapies have been shown to boost a tumor-specific immune response, not all patients respond and prognostic biomarkers are scarce. In this study, we determined the peripheral blood T cell receptor β (TCRβ) chain repertoire of nine MPM patients before and 5 weeks after the start of...

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PMID: 32234848
DOI: 10.1136/jitc-2019-000251

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