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Article

Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30.

Cell reports - 31 Mar 2020

Rizzotto Dario, Zaccara Sara, Rossi Annalisa, Galbraith Matthew D, Andrysik Zdenek, Pandey Ahwan, Sullivan Kelly D, Quattrone Alessandro, Espinosa Joaquín M, Dassi Erik, Inga Alberto

Abstract excerpt

Activation of p53 by the small molecule Nutlin can result in a combination of cell cycle arrest and apoptosis. The relative strength of these events is difficult to predict by classical gene expression analysis, leaving uncertainty as to the therapeutic benefits. In this study, we report a translational control mechanism shaping p53-dependent apoptosis. Using polysome profiling, we establish Nutlin-induced...

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Identifiers

PMID: 32234473
DOI: 10.1016/j.celrep.2020.03.011
PMCID: PMC7182397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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