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Article

Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models

17 Nov 2021

Abstract excerpt

Aberrant alternative pre-mRNA splicing plays a critical role in MYC-driven cancers and therefore may represent a therapeutic vulnerability. Here, we show that neuroblastoma, a MYC-driven cancer characterized by splicing dysregulation and spliceosomal dependency, requires the splicing factor RBM39 for survival. Indisulam, a “molecular glue” that selectively recruits RBM39 to the CRL4-DCAF15 E3 ubiquitin ligase for...

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PMID: 34788094
DOI: 10.1126/sciadv.abj5405

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