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Article

The insulator functions of the Drosophila polydactyl C2H2 zinc finger protein CTCF: Necessity versus sufficiency.

Science advances - 1 Mar 2020

Kyrchanova Olga, Maksimenko Oksana, Ibragimov Airat, Sokolov Vladimir, Postika Nikolay, Lukyanova Maria, Schedl Paul, Georgiev Pavel

Abstract excerpt

In mammals, a C2H2 zinc finger (C2H2) protein, CTCF, acts as the master regulator of chromosomal architecture and of the expression of Hox gene clusters. Like mammalian CTCF, the Drosophila homolog, dCTCF, localizes to boundaries in the bithorax complex (BX-C). Here, we have determined the minimal requirements for the assembly of a functional boundary by dCTCF and two other C2H2 zinc finger proteins, Pita and...

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Identifiers

PMID: 32232161
DOI: 10.1126/sciadv.aaz3152
PMCID: PMC7096168

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