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Article

Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.

PLoS genetics - 1 Jul 2016

Kyrchanova Olga, Mogila Vladic, Wolle Daniel, Deshpande Girish, Parshikov Alexander, Cléard Fabienne, Karch Francois, Schedl Paul, Georgiev Pavel

Abstract excerpt

Functionally autonomous regulatory domains direct the parasegment-specific expression of the Drosophila Bithorax complex (BX-C) homeotic genes. Autonomy is conferred by boundary/insulator elements that separate each regulatory domain from its neighbors. For six of the nine parasegment (PS) regulatory domains in the complex, at least one boundary is located between the domain and its target homeotic gene....

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Identifiers

PMID: 27428541
DOI: 10.1371/journal.pgen.1006188
PMCID: PMC4948906

Genes

PTS
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.PMID 27428541Read ↗

Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.Semantic proximity Read ↗

The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain.Semantic proximity Read ↗

In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element.Semantic proximity Read ↗

The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex.Semantic proximity Read ↗

The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.Semantic proximity Read ↗

A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation.Semantic proximity Read ↗

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