Article
Minimal phenotyping yields genome-wide association signals of low specificity for major depression.
Nature genetics - 1 Apr 2020
Cai Na, Revez Joana A, Adams Mark J, Andlauer Till F M, Breen Gerome, Byrne Enda M, Clarke Toni-Kim, Forstner Andreas J, Grabe Hans J, Hamilton Steven P, Levinson Douglas F, Lewis Cathryn M, Lewis Glyn, Martin Nicholas G, Milaneschi Yuri, Mors Ole, Müller-Myhsok Bertram, Penninx Brenda W J H, Perlis Roy H, Pistis Giorgio, Potash James B, Preisig Martin, Shi Jianxin, Smoller Jordan W, Streit Fabien, Tiemeier Henning, Uher Rudolf, Van der Auwera Sandra, Viktorin Alexander, Weissman Myrna M, Kendler Kenneth S, Flint Jonathan
Abstract excerpt
Minimal phenotyping refers to the reliance on the use of a small number of self-reported items for disease case identification, increasingly used in genome-wide association studies (GWAS). Here we report differences in genetic architecture between depression defined by minimal phenotyping and strictly defined major depressive disorder (MDD): the former has a lower genotype-derived heritability that cannot be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.