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Article

Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype.

European journal of immunology - 1 Aug 2020

Aye Racheal, Sutton Henry J, Nduati Eunice W, Kai Oscar, Mwacharo Jedida, Musyoki Jennifer, Otieno Edward, Wambua Juliana, Bejon Philip, Cockburn Ian A, Ndungu Francis M

Abstract excerpt

Atypical memory B cells (aMBCs) are found in elevated numbers in individuals exposed to malaria. A key question is whether malaria induces aMBCs as a result of exposure to Ag, or non-Ag-specific mechanisms. We identified Plasmodium and bystander tetanus toxoid (TT) specific B cells in individuals from areas of previous and persistent exposure to malaria using tetramers. Malaria-specific B cells were more likely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32222961
DOI: 10.1002/eji.201948473
PMCID: PMC7611263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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