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Article

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens.

PLoS pathogens - 1 Oct 2024

Reyes Raphael A, Turner Louise, Ssewanyana Isaac, Jagannathan Prasanna, Feeney Margaret E, Lavstsen Thomas, Greenhouse Bryan, Bol Sebastiaan, Bunnik Evelien M

Abstract excerpt

Plasmodium falciparum infections elicit strong humoral immune responses to two main groups of antigens expressed by blood-stage parasites: merozoite antigens that are involved in the erythrocyte invasion process and variant surface antigens that mediate endothelial sequestration of infected erythrocytes. Long-lived B cells against both antigen classes can be detected in the circulation for years after exposure,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39466842
DOI: 10.1371/journal.ppat.1012661
PMCID: PMC11542837

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