Article
The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2016
Hart Geoffrey T, Akkaya Munir, Chida Asiya S, Wei Chungwen, Jenks Scott A, Tipton Christopher, He Chenfeng, Wendel Ben S, Skinner Jeff, Arora Gunjan, Kayentao Kassoum, Ongoiba Aissata, Doumbo Ogobara, Traore Boubacar, Narum David L, Jiang Ning, Crompton Peter D, Sanz Ignacio, Pierce Susan K
Abstract excerpt
Plasmodium falciparum malaria is a deadly infectious disease in which Abs play a critical role in naturally acquired immunity. However, the specificity and nature of Abs elicited in response to malaria are only partially understood. Autoreactivity and polyreactivity are common features of Ab responses in several infections and were suggested to contribute to effective pathogen-specific Ab responses. In this...
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