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Article

Resist the Temptation of Response-Adaptive Randomization

26 Mar 2020

Abstract excerpt

Response-adaptive randomization (RAR) has recently gained popularity in clinical trials. The intent is noble: minimize the number of participants randomized to inferior treatments and increase the amount of information about better treatments. Unfortunately, RAR causes many problems, including (1) bias from temporal trends, (2) inefficiency in treatment effect estimation, (3) volatility in sample-size...

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PMID: 32222766
DOI: 10.1093/cid/ciaa334

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