Article

A Sequential Multiple Assignment Randomized Trial Design with Response-Adaptive Tailoring Function

2026-04-29

Abstract excerpt

We present a novel sequential multiple assignment randomized trial (SMART) design that integrates response-adaptive randomization with tailoring functions (RA-TF-SMART). We develop percentile-based and Z-score RA-TFs that incorporate both within-patient and between-patient adaptation to map continuous outcomes to randomization probabilities. We apply Q-learning, tree-based reinforcement learning, and G-estimation...

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Literature Corpus work: 5d5f054e-b220-5e5d-9e74-f78efa5bd34a
DOI: 10.64898/2026.04.28.26351992

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