Article
Nature as a Trialist?: Deconstructing the Analogy Between Mendelian Randomization and Randomized Trials.
Epidemiology (Cambridge, Mass.) - 1 Sept 2017
Swanson Sonja A, Tiemeier Henning, Ikram M Arfan, Hernán Miguel A
Abstract excerpt
Mendelian randomization (MR) studies are often described as naturally occurring randomized trials in which genetic factors are randomly assigned by nature. Conceptualizing MR studies as randomized trials has profound implications for their design, conduct, reporting, and interpretation. For example, analytic practices that are discouraged in randomized trials should also be discouraged in MR studies. Here, we...
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