Article

Two Stage Designs for Phase III Clinical Trials

2020-08-03

Abstract excerpt

Phase III platform trials are increasingly used to evaluate a sequence of treatments for a specific disease. Traditional approaches to structure such trials tend to focus on the sequential questions rather than the performance of the entire enterprise. We consider two-stage trials where an early evaluation is used to determine whether to continue with an individual study. To evaluate performance, we use the ratio...

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Literature Corpus work: b8782f5b-309c-5f68-bc86-c6d6c07fe83c
DOI: 10.1101/2020.07.29.20164525

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