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Article

Distance dependent shedding of IL-6R.

Biochemical and biophysical research communications - 28 May 2020

Düsterhöft Stefan, Bartels Anne-Kathrin, Koudelka Tomas, Lilienthal Eva, Schäfer Miriam, Garbers Christoph, Tholey Andreas, Grötzinger Joachim, Lorenzen Inken

Abstract excerpt

Proteolytic processing of membrane proteins by A disintegrin and metalloprotease-17 (ADAM17) is a key regulatory step in many physiological and pathophysiological processes. This so-called shedding is essential for development, regeneration and immune defense. An uncontrolled ADAM17 activity promotes cancer development, chronic inflammation and autoimmune diseases. Consequently, the ADAM17 activity is tightly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32222277
DOI: 10.1016/j.bbrc.2020.03.093

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