The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

doi:10.1016/j.bbadis.2014.05.018

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Article

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

Biochimica et biophysica acta - 1 Sept 2014

Garbers Christoph, Monhasery Niloufar, Aparicio-Siegmund Samadhi, Lokau Juliane, Baran Paul, Nowell Mari A, Jones Simon A, Rose-John Stefan, Scheller Jürgen

Abstract excerpt

The pleiotropic activities of Interleukin (IL-)6 are controlled by membrane-bound and soluble forms of the IL-6 receptor (IL-6R) in processes called classic and trans-signaling, respectively. The coding single nucleotide polymorphism (SNP) rs2228145 of the Interleukin 6 receptor (IL-6R Asp358Ala variant) is associated with a 2-fold increase in soluble IL-6R (sIL-6R) serum levels resulting in reduced IL-6-induced...

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PMID: 24878322
DOI: 10.1016/j.bbadis.2014.05.018

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