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Article

Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability.

Journal for immunotherapy of cancer - 1 Mar 2020

Yang Yuanquan, Jain Rohit K, Glenn Sean T, Xu Bo, Singh Prashant K, Wei Lei, Hu Qiang, Long Mark, Hutson Nicholas, Wang Jianming, Battaglia Sebastiano, George Saby

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) occurs in 3% of urothelial carcinomas as a result of germline or somatic loss of function mutation in mismatch repair (MMR) proteins.1 Although MSH4 is a member of the DNA MMR mutS family, the association of MSH4 mutation with MSI has not been described. We report a complete responder to PD-L1 blockade who had MSH4 mutated metastatic bladder cancer with mixed histology...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32221012
DOI: 10.1136/jitc-2019-000128
PMCID: PMC7206971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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