Back to search

Article

Real-world Concordance in Microsatellite Instability Status Between PCR-based Testing and Next-Generation Sequencing Assay for Solid Tumors

2021-05-28

Abstract excerpt

<h4>Background: </h4> Various malignancies exhibit high microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR). The MSI-IVD kit, which can detect MSI status using a polymerase chain reaction (PCR)-based method, was approved as the first tumor-agnostic companion diagnostic for pembrolizumab in patients with MSI-H solid tumors in Japan. Recently, next-generation sequencing (NGS), which can also dete...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7368c5a4-d053-5d0f-a5fb-4ec8cd5cf47a
DOI
10.21203/rs.3.rs-558267/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Real-world Concordance in Microsatellite Instability Status Between PCR-based Testing and Next-Generation Sequencing Assay for Solid TumorsDOI 10.21203/rs.3.rs-558267/v1
Concordance analysis of microsatellite instability status between polymerase chain reaction based testing and next generation sequencing for solid tumorsSemantic proximity
Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients.Semantic proximity
Real-World Evaluation of Microsatellite Instability Detection via Targeted NGS Panels in Routine Molecular DiagnosticsSemantic proximity
Microsatellite instability: A 2024 update.Semantic proximity
Analysis of Concordance Between Next-Generation Sequencing Assessment of Microsatellite Instability and Immunohistochemistry-Mismatch Repair From Solid TumorsSemantic proximity
Pan-Cancer Prevalence of Microsatellite Instability-High (MSI-H) Identified by Circulating Tumor DNA and Associated Real-World Clinical OutcomesSemantic proximity
Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in CancersSemantic proximity
Genomic landscape of microsatellite instability in Chinese tumors: A comparison of Chinese and TCGA cohortsSemantic proximity
Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: ASCO Endorsement of College of American Pathologists GuidelineSemantic proximity
Microsatellite Instability as a Biomarker for PD-1 BlockadeSemantic proximity
Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancersSemantic proximity
Evaluation of Micro Satellite Instability and Mismatch Repair Status in Different Solid Tumors: A Multicenter Analysis in a Real World SettingSemantic proximity
Select a neighboring publication to make it the new centre.