Article

Low MSH2 protein levels identify muscle-invasive bladder cancer resistant to cisplatin

2018-06-29

Abstract excerpt

<h4>Background</h4> The response to first-line, platinum-based treatment of muscle-invasive bladder cancer has not improved in three decades. <h4>Objective</h4> The objective of this study is to identify genes that predict cisplatin resistance in bladder cancer. <h4>Design</h4> We performed a whole-genome, CRISPR-based screen in a bladder cancer cell line treated with cisplatin to identify genes that mediate re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b05315e0-1921-5526-b2de-023f7766eaad
DOI: 10.1101/359554

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low MSH2 protein levels identify muscle-invasive bladder cancer resistant to cisplatinDOI 10.1101/359554Read

Doctors revise Declaration of HelsinkiSemantic proximity Read

Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer.Semantic proximity Read

Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma.Semantic proximity Read

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder CancerSemantic proximity Read

Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability.Semantic proximity Read

NPEPPS is a novel and druggable driver of platinum resistanceSemantic proximity Read

Alterations in DNA Damage Repair Genes Before and After Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder CancerSemantic proximity Read

Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis.Semantic proximity Read

CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancerSemantic proximity Read

Quantitative functional profiling of ERCC2 mutations deciphers cisplatin sensitivity in bladder cancerSemantic proximity Read

Microsatellite Instability Analysis (MSA) for Bladder Cancer: Past History and Future DirectionsSemantic proximity Read

Effects and mechanisms of AMIGO2 in proliferation, migration and drug resistance of bladder cancerSemantic proximity Read