Article
A rapidly reversible mutation generates subclonal genetic diversity and unstable drug resistance.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2021
Dan Lufeng, Li Yuze, Chen Shuhua, Liu Jingbo, Wang Yu, Li Fangting, He Xiangwei, Carey Lucas B
Abstract excerpt
Most genetic changes have negligible reversion rates. As most mutations that confer resistance to an adverse condition (e.g., drug treatment) also confer a growth defect in its absence, it is challenging for cells to genetically adapt to transient environmental changes. Here, we identify a set of rapidly reversible drug-resistance mutations in Schizosaccharomyces pombe that are caused by microhomology-mediated...
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