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Anti-HIV agent azidothymidine decreases Tet(X)-mediated bacterial resistance to tigecycline in Escherichia coli

3 Apr 2020

Abstract excerpt

Recent emergence of high-level tigecycline resistance mediated by Tet(X3/X4) in Enterobacteriaceae undoubtably constitutes a serious threat for public health worldwide. Antibiotic adjuvant strategy makes antibiotic more effective against these resistant pathogens through interfering intrinsic resistance mechanisms or enhancing antibiotic actions. Herein, we screened a collection of drugs to identify compounds...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32246108
DOI: 10.1038/s42003-020-0877-5

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