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Mutant Huntingtin affects toll-like receptor 4 intracellular trafficking and cytokine production in mast cells

27 Mar 2020

Abstract excerpt

Abstract Background Huntington’s disease (HD) is caused by the expression of a mutated variant of Huntingtin (mHtt), which results in the complex pathology characterized by a defective function of the nervous system and altered inflammatory responses. While the neuronal effects of mHtt expression have been extensively studied, its effects on the physiology of immune cells have not been fully described. Mast cells...

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PMID: 32220257
DOI: 10.1186/s12974-020-01758-9

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