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Article

A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice.

Nature communications - 16 Dec 2016

Sibilano Riccardo, Gaudenzio Nicolas, DeGorter Marianne K, Reber Laurent L, Hernandez Joseph D, Starkl Philipp M, Zurek Oliwia W, Tsai Mindy, Zahner Sonja, Montgomery Stephen B, Roers Axel, Kronenberg Mitchell, Yu Mang, Galli Stephen J

Abstract excerpt

Asthma has multiple features, including airway hyperreactivity, inflammation and remodelling. The TNF superfamily member TNFSF14 (LIGHT), via interactions with the receptor TNFRSF14 (HVEM), can support TH2 cell generation and longevity and promote airway remodelling in mouse models of asthma, but the mechanisms by which TNFSF14 functions in this setting are incompletely understood. Here we find that mouse and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Dermatophagoides

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Source

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Identifiers

PMID: 27982078
DOI: 10.1038/ncomms13696
PMCID: PMC5171877

Genes

TNFRSF14
TNFSF14
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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