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Article

Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2011

Li Hongmei, Nourbakhsh Bardia, Safavi Farinaz, Li Ke, Xu Hui, Cullimore Melissa, Zhou Fang, Zhang Guangxian, Rostami Abdolmohamad

Abstract excerpt

Mast cells (MCs) have been thought to play a pathogenic role in the development of autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. However, an immunoregulatory function of these cells has recently been suggested. We investigated the role of MCs in EAE using the W(-sh) mouse strain, which is MC deficient. W(-sh) mice developed earlier and more...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21646293
DOI: 10.4049/jimmunol.1003603
PMCID: PMC4201114

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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