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Article

FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade

22 Nov 2021

Abstract excerpt

Morphologically distinct TDP-43 aggregates occur in clinically different FTLD-TDP subtypes, yet the mechanism of their emergence and contribution to clinical heterogeneity are poorly understood. Several lines of evidence suggest that pathological TDP-43 follows a prion-like cascade, but the molecular determinants of this process remain unknown. We use advanced microscopy techniques to compare the seeding...

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PMID: 34806807
DOI: 10.15252/embr.202153877

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