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Article

ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia-related changes and normal karyotype.

Cancer medicine - 1 Jun 2020

Prats-Martín Concepción, Burillo-Sanz Sergio, Morales-Camacho Rosario M, Pérez-López Olga, Suito Milagros, Vargas Maria T, Caballero-Velázquez Teresa, Carrillo-Cruz Estrella, González José, Bernal Ricardo, Pérez-Simón José A

Abstract excerpt

Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) are poor outcome leukemias. Its diagnosis is based on clinical, cytogenetic, and cytomorphologic criteria, last criterion being sometimes difficult to assess. A high frequency of ASXL1 mutations have been described in this leukemia. We sequenced ASXL1 gene mutations in 61 patients with AML-MRC and 46 controls with acute myeloid leukemia without...

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PMID: 32216059
DOI: 10.1002/cam4.2947
PMCID: PMC7286456

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