Article
Cloning of CYP2J2 gene and identification of functional polymorphisms.
Molecular pharmacology - 1 Apr 2002
King Lorraine M, Ma Jixiang, Srettabunjong Supawon, Graves Joan, Bradbury J Alyce, Li Leping, Spiecker Martin, Liao James K, Mohrenweiser Harvey, Zeldin Darryl C
Abstract excerpt
CYP2J2 is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that possess potent anti-inflammatory, vasodilatory, and fibrinolytic properties. We cloned and sequenced the entire CYP2J2 gene (approximately 40.3 kb), which contains nine exons and eight introns. We then sequenced the CYP2J2 exons and intron-exon boundaries in 72 healthy persons representing African,...
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