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Article

Variability of CYP2J2 expression in human fetal tissues.

The Journal of pharmacology and experimental therapeutics - 1 Nov 2006

Gaedigk Andrea, Baker Darren W, Totah Rheem A, Gaedigk Roger, Pearce Robin E, Vyhlidal Carrie A, Zeldin Darryl C, Leeder J Steven

Abstract excerpt

CYP2J2 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids (EETs), which play a critical role in the regulation of renal, pulmonary, cardiac, and vascular function. However, the contribution of CYP2J2 to EET formation in the liver remains poorly characterized. Likewise, information is sparse regarding the extent and variability of CYP2J2 expression during human...

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Identifiers

PMID: 16868033
DOI: 10.1124/jpet.106.109215
PMCID: PMC1876721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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