Article

AAV tools enable functional modulation and readout of central and peripheral nervous systems in spiny mice

2026-05-13

Abstract excerpt

Among mammals, spiny mice ( Acomys spp.) exhibit the unique capacity to regenerate parts of their nervous system. Studying this phenomenon has the potential to reveal new targets that can slow or halt human neurodegenerative disorders. Unfortunately, research tools (e.g., transgenic lines, gene delivery vehicles) are lacking compared to those available for other rodent models. Here, we tested systemic adeno-assoc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0808e15-c271-51aa-9ea1-2ac9b852c7dd
DOI: 10.64898/2026.05.08.723863

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AAV tools enable functional modulation and readout of central and peripheral nervous systems in spiny miceDOI 10.64898/2026.05.08.723863Read

Central and peripheral delivery of AAV9-SMN target different pathomechanisms in a mouse model of spinal muscular atrophySemantic proximity Read

Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice.Semantic proximity Read

Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile miceSemantic proximity Read

Preclinical Evaluation of AAV9-coSMN1 Gene Therapy for Spinal Muscular Atrophy：Efficacy and Safety in Mouse Models and Non-Human PrimatesSemantic proximity Read

Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System.Semantic proximity Read

Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaqueSemantic proximity Read

A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencingSemantic proximity Read

Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and ProspectsSemantic proximity Read

Intramuscular scAAV9-SMN Injection Mediates Widespread Gene Delivery to the Spinal Cord and Decreases Disease Severity in SMA MiceSemantic proximity Read

Onasemnogene abeparvovec for the treatment of spinal muscular atrophy.Semantic proximity Read

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates, and humansSemantic proximity Read

Systemic delivery of scAAV9 in fetal macaques facilitates neuronal transduction of the central and peripheral nervous systemsSemantic proximity Read