Article
Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour.
eLife - 25 Mar 2020
García-González Judit, Brock Alistair J, Parker Matthew O, Riley Riva J, Joliffe David, Sudwarts Ari, Teh Muy-Teck, Busch-Nentwich Elisabeth M, Stemple Derek L, Martineau Adrian R, Kaprio Jaakko, Palviainen Teemu, Kuan Valerie, Walton Robert T, Brennan Caroline H
Abstract excerpt
To facilitate smoking genetics research we determined whether a screen of mutagenized zebrafish for nicotine preference could predict loci affecting smoking behaviour. From 30 screened F3 sibling groups, where each was derived from an individual ethyl-nitrosurea mutagenized F0 fish, two showed increased or decreased nicotine preference. Out of 25 inactivating mutations carried by the F3 fish, one in the slit3...
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