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Article

Motoneuron axon pathfinding errors in zebrafish: differential effects related to concentration and timing of nicotine exposure.

Toxicology and applied pharmacology - 1 Apr 2015

Menelaou Evdokia, Paul Latoya T, Perera Surangi N, Svoboda Kurt R

Abstract excerpt

Nicotine exposure during embryonic stages of development can affect many neurodevelopmental processes. In the developing zebrafish, exposure to nicotine was reported to cause axonal pathfinding errors in the later born secondary motoneurons (SMNs). These alterations in SMN axon morphology coincided with muscle degeneration at high nicotine concentrations (15-30 μM). Previous work showed that the paralytic mutant...

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Identifiers

PMID: 25668718
DOI: 10.1016/j.taap.2015.01.022
PMCID: PMC4567840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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