Article
Nicotine response genetics in the zebrafish.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009
Petzold Andrew M, Balciunas Darius, Sivasubbu Sridhar, Clark Karl J, Bedell Victoria M, Westcot Stephanie E, Myers Shelly R, Moulder Gary L, Thomas Mark J, Ekker Stephen C
Abstract excerpt
Tobacco use is predicted to result in over 1 billion deaths worldwide by the end of the 21(st) century. How genetic variation contributes to the observed differential predisposition in the human population to drug dependence is unknown. The zebrafish (Danio rerio) is an emerging vertebrate model system for understanding the genetics of behavior. We developed a nicotine behavioral assay in zebrafish and applied it...
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