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Article

From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics.

Pharmacogenetics and genomics - 1 Mar 2009

Chu Larry F, Liang De-Yong, Li Xiangqi, Sahbaie Peyman, D'arcy Nicole, Liao Guochun, Peltz Gary, David Clark J

Abstract excerpt

OBJECTIVES: Addiction to opioid narcotics represents a major public health challenge. Animal models of one component of addiction, physical dependence, show this trait to be highly heritable. The analysis of opioid dependence using contemporary in-silico techniques offers an approach to discover novel treatments for dependence and addiction. METHODS: In these experiments, opioid withdrawal behavior in 18 inbred...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19214139
DOI: 10.1097/FPC.0b013e328322e73d
PMCID: PMC2730361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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