Article
Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine.
Genome biology - 1 Jan 2009
Webb Katharine J, Norton William Hj, Trümbach Dietrich, Meijer Annemarie H, Ninkovic Jovica, Topp Stefanie, Heck Daniel, Marr Carsten, Wurst Wolfgang, Theis Fabian J, Spaink Herman P, Bally-Cuif Laure
Abstract excerpt
BACKGROUND: Addiction is a pathological dysregulation of the brain's reward systems, determined by several complex genetic pathways. The conditioned place preference test provides an evaluation of the effects of drugs in animal models, allowing the investigation of substances at a biologically relevant level with respect to reward. Our lab has previously reported the development of a reliable conditioned place...
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