Article
D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2020
Mansouri Esmaeil, Nobrega José N, Hill Matthew N, Tyndale Rachel F, Lee Francis S, Hendershot Christian S, Best Laura M, Di Ciano Patricia, Balsevich Georgia, Sloan Mathew E, Kish Stephen J, Tong Junchao, Le Foll Bernard, Boileau Isabelle
Abstract excerpt
The endocannabinoid and dopaminergic systems have independently been implicated in substance use disorder and obesity. We investigated a potential interaction between genetically inherited variation in fatty acid amide hydrolase (FAAH, C385A), which metabolizes the cannabis-like endocannabinoid anandamide, and dopaminergic system, measured by dopamine receptor levels and mRNA. Binding of the dopamine D3...
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