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Meta-GWAS of PCSK9 levels detects two novel loci atAPOBandTM6SF2

16 Sept 2021

Abstract excerpt

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player in lipid metabolism, as it degrades low-density lipoprotein (LDL) receptors from hepatic cell membranes. So far, only variants of the PCSK9 gene locus were found to be associated with PCSK9 levels. Here we aimed to identify novel genetic loci that regulate PCSK9 levels and how they relate to other lipid traits. Additionally, we...

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PMID: 34590679
DOI: 10.1093/hmg/ddab279

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