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Melatonin Enhances the Development of Porcine Cloned Embryos by Improving DNA Methylation Reprogramming

24 Mar 2020

Abstract excerpt

Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning efficiency. Melatonin has been proven to improve the development of cloned embryos, however, the role of melatonin during somatic cell nuclear transfer remains unclear. This work demonstrated that 10−7 M melatonin significantly enhanced the developmental progress, reduced the arrested rate before zygotic genome activation, and...

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Share to Epigenetics and DNA Methylation
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PMID: 32207988
DOI: 10.1089/cell.2019.0103

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